PMC

(A) Superposition of the TAdV-3 fibre head monomer onto the mammalian reovirus sigma1 head domain and the porcine adenovirus 4 NADC-1 strain fibre head domain (B). Superposition of the TAdV-3 fibre head monomer onto the mammalian reovirus sigma1 head domain and the porcine adenovirus 4 NADC-1 strain fibre head domain The TAdV-3 fibre head monomer is shown in green, the sigma1 head domain in orange and the porcine adenovirus 4 NADC-1 strain fibre head domain in blue. An asterisk shows the location of the DG-loops, it can be seen that the DG-loop of the TAdV-3 fibre head is shorter than its reovirus sigma 1 and porcine adenovirus 4 NADC-1 strain fibre head counterparts.

a Structure of the designed flexible optical fibre. b, c Photographs of the OE fibre core with PDMS cladding and the light guiding in the optical fibre. Green laser was launched into the fibre through a coupled silica multimode optical fibre. d Photograph of the cross section of the OE fibre core with PDMS cladding. e Propagation loss of the OE fibre core with and without PDMS cladding measured by a cutback method in air condition. f, g Photographs of the as-fabricated fibre sensor with 365 nm LED off or on. h Cross section of the fabricated optical fibre sensor. i Photograph of the as-fabricated flexible optical fibre sensor integrated with Li₂Zn_0.85SiO₄:0.15Mn²⁺ phosphor under natural-light irradiation.

A, example of a recording from a Purkinje cell with inputs from four different climbing fibres. B, input–output graph of the same recording as in A, which shows a stepwise increase in amplitude of the climbing fibre EPSC upon a gradual increase in stimulus strength, indicating four climbing fibres innervating the recorded Purkinje cell. C, number of climbing fibres in WT and 5-HT_3A receptor knockout mice between P5 and P24 shows a delay in climbing fibre elimination in 5-HT_3A receptor knockout mice. D, the climbing fibre ratio, defined as the amplitude of one climbing fibre EPSC divided by the amplitude of the largest climbing fibre EPSC within the same Purkinje cell, is increased in 5-HT_3A receptor knockout mice at P7 and P8. E, there is no difference in the amplitude of the smallest climbing fibre EPSC between WT and 5-HT_3A receptor knockout mice at P6–P12. Only at P5 is the amplitude of the smallest climbing fibre EPSC smaller in 5-HT_3A receptor knockout mice. At P24 there was only one climbing fibre innervating each Purkinje cell in WT mice, which we counted as the climbing fibre with the largest climbing fibre EPSC and thus there is no value for the amplitude of the smallest climbing fibre EPSC in P24 WT mice. F, the amplitude of the largest climbing fibre EPSC is decreased at P5, P7 and P8 in 5-HT_3A receptor knockout mice, accounting for the increase in climbing fibre ratio as shown in C.

HR and 95%CI for B2 (A), M (B), G2 (C) and VB (D) stratified by cereal fibre intakes. Data are HR with 95% confidence intervals. Cox proportional hazard regression models were used, adjusted for parental education level, mother’s age at menarche, energy intake at baseline and percent body fat at baseline, with the group of those in the lowest tertile of both total soy and dietary cereal fibre intakes serving as the reference group. p for interactions refers to the 2-way interactions of cereal fibre intakes on the relations between dietary soy intake and puberty markers. A, B N_girl=2152. Range of soybean intakes: 1st tertile (0–8.2), 2nd tertile (8.5–39.6) and 3rd tertile (40.1–69.0). Participants in groups: low soy, low cereal fibre: n=285; low soy, medium cereal fibre: n=217; low soy, high cereal fibre: n=222; medium soy, low cereal fibre: n=265; medium soy, medium cereal fibre: n=223; medium soy, high cereal fibre: n=220; high soy, low cereal fibre: n=309; high soy, medium cereal fibre: n=221; high soy, high cereal fibre: n=192. C, D N_boy=2629. Range of soybean intakes: 1st tertile (0–3.2), 2nd tertile (4.6–48 2) and 3rd tertile (49.1–82.6). Participants in groups: low soy, low cereal fibre: n=350; low soy, medium cereal fibre: n=266; low soy, high cereal fibre: n=269; medium soy, low cereal fibre: n=320; medium soy, medium cereal fibre: n=272; medium soy, high cereal fibre: n=268; high soy, low cereal fibre: n=376; high soy, medium cereal fibre: n=274; high soy, high cereal fibre: n=234